F_mbjzUCnrjkXsrs461D32YJD9CGWQoWwptvxTREeMo MIVACRON (mivacurium chloride)
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FAST OFFSET (AVERAGE TIME 12-13 MINUTES ACROSS ALL DOSES) FROM NEUROMUSCULAR BLOCKAGE1,2*

Recovery index with MIVACRON® (mivacurium chloride) is independent of dose and duration of administration1,2

recovery graph

*Offset for all doses was the time interval between 25% recovery to T4/T1 ratio recovery ≥75%

Comparative mean spontaneous recovery curves of single twitch following various bolus doses. Measurements are from 5%-95% twitch recovery. Intervals from 25%-75% and from 5%-95% twitch recovery do not differ significantly.2

Time to spontaneous recovery in MIVACRON clinical trials¹

recovery graph

     

     

     

  1. Values shown are medians of means from individual studies (range of individual patient values)
  2. Doses administered over 5–15 seconds 
  3. Clinically effective duration of neuromuscular block
  4. Data available for as few as 40% of adults in specific dose groups and for 22% of children in the 0.2 mg/kg dose group due to administration of reversal agents or additional doses of MIVACRON prior to 95% recovery or T4/T1 ratio recovery to ≥75%
  5. Rapid administration not recommended due to possibility of decreased blood pressure. Administer 0.2 mg/kg over 30 seconds; administer 0.25 mg/kg as divided dose (0.15 mg/kg followed 30 seconds later by 0.1 mg/kg)
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MIVACRON

efficacy and safety

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Safety Considerations1

  • MIVACRON may have profound neuromuscular blocking effects in cachectic or debilitated patients, patients with neuromuscular diseases, and patients with carcinomatosis. In these or other patients in whom potentiation of neuromuscular block or difficulty with reversal may be anticipated, the initial dose should be decreased.
  • As seen with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at the time of reversal, the longer the time and the greater the dose of anticholinesterase agent required for recovery of neuromuscular function.