F_mbjzUCnrjkXsrs461D32YJD9CGWQoWwptvxTREeMo MIVACRON (mivacurium chloride)
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Time to generally good-to-excellent intubating conditions¹

intubation chart

*Dosing range studied: 0.15 mg/kg (2.5-3 mins) to 0.25 mg/kg (1.5-2 mins)

After completion of 0.15 mg/kg to 0.25 mg/kg dose

When administered during the induction of adequate general anesthesia using thiopental or propofol, nitrous oxide/oxygen, and coinduction agents such as fentanyl and/or midazolam, doses of 0.15 mg/kg (2 x ED95) MIVACRON administered over 5-15 seconds or 0.2 mg/kg MIVACRON administered over 30 seconds produced generally good-to-excellent tracheal intubation conditions in 2.5-3 and 2-2.5 minutes, respectively. A dose of 0.25 mg/kg MIVACRON administered as a divided dose (0.15 mg/kg followed 30 seconds later by 0.1 mg/kg) produced generally good-to-excellent intubation conditions in 1.5-2 minutes after initiating the dosing regimen.¹

Timing of intubation

For optimal intubating results

  • Visually examine the vocal cords 90 seconds after the first dose of MIVACRON
  • The cords should be relaxed, indicating that conditions are right for successful intubation

Use multiple criteria to guide the time of intubation

  • Reliance upon twitch monitoring of the adductor pollicis may result in waiting too long and therefore missing the time frame for optimal intubating conditions
  • All four twitches of the train-of-four response may be present, with little or no fade, at the times recommended for intubation¹

As with other neuromuscular blocking agents, it is important to use other criteria, such as clinical evaluation of the status of relaxation of jaw muscular and vocal cords, in conjunction with peripheral muscle twitch monitoring, to guide the appropriate time of intubation¹

Safety Considerations1

MIVACRON should only be administered intravenously in carefully adjusted dosage by or under the supervision of experienced clinicians who are familiar with the drug's actions and the possible complications.