NIMBEX Intubation Dosing for Adults1,a

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NIMBEX has an intermediate onset of action and is not recommended for rapid sequence endotracheal intubation.

It is recommended that a peripheral nerve stimulator be used during the administration of NIMBEX to monitor drug effect, determine the need for additional doses, and confirm recovery from neuromuscular block.

In a study at a dose of 0.1 mg/kg, time to maximum block was approximately 1 minute slower in elderly patients (≥65 years) than in healthy young adults; onset time was approximately 1 minute faster in patients with end-stage liver disease and time to 90% block was approximately 1 minute slower in patients with renal disease than in healthy adult control patients.
bTime to 25% spontaneous recovery.
c Coinduction agents: midazolam and fentanyl.
d Propofol/N2O/O2 anesthesia.

NIMBEX Maintenance Dosing for Adults1,a

Body Weight

Kg

adultmaintenance

 

NIMBEX has an intermediate onset of action and is not recommended for rapid sequence endotracheal intubation.

It is recommended that a peripheral nerve stimulator be used during the administration of NIMBEX to monitor drug effect, determine the need for additional doses, and confirm recovery from neuromuscular block.

aTime to 25% spontaneous recovery.
bCoinduction agents: midazolam and fentanyl.
c Propofol/N2O/O2 anesthesia.

NIMBEX Infusion Dosing for Adults and Children

infusiondosing

A diluted solution of NIMBEX can be administered by continuous infusion in adults and children ≥2 years old during extended surgical procedures.

a Opioid/N2O/O2 anesthesia
b Infusion of NIMBEX should be initiated only after early evidence of spontaneous recovery from the initial bolus dose. A rate of 1 to 2 mcg/kg/min should be adequate to maintain continuous NMB block in the range of 89% to 99% in most pediatric and adult patients under opioid/N2O/O2 anesthesia.

 

It is recommended that a peripheral nerve stimulator be used during the administration of NIMBEX to monitor drug effect, determine the need for additional doses, and confirm recovery from neuromuscular block.

Spontaneous recovery following the discontinuation of infusion of NIMBEX may be expected to proceed at a rate comparable to that of a single bolus dose.

NIMBEX Intubation Dosing for Children (2-12 years)1

childrenintubation

 

NIMBEX has an intermediate onset of action and is not recommended for rapid sequence endotracheal intubation.

It is recommended that a peripheral nerve stimulator be used during the administration of NIMBEX to monitor drug effect, determine the need for additional doses, and confirm recovery from neuromuscular block.

aTime to 25% spontaneous recovery.
bAdministered over 5 to 10 seconds during halothane or opioid anesthesia.
c Opioid/N2O/O2 anesthesia.

NIMBEX Intubation Dosing for Infants (under 2 years)1

infantintubation

 

NIMBEX has an intermediate onset of action and is not recommended for rapid sequence endotracheal intubation.

It is recommended that a peripheral nerve stimulator be used during the administration of NIMBEX to monitor drug effect, determine the need for additional doses, and confirm recovery from neuromuscular block.

aThe 10-mL multiple-dose vial is contraindicated for use in premature infants because it contains benzyl alcohol.
bTime to 25% spontaneous recovery.
cAdministered over 5 to 10 seconds during halothane or opioid anesthesia.
dThiopentone/alfentanil/N2O/O2 anesthesia.

 

Dosing should be Individualized. These examples are a guide only.

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