Fat Solubility

Does fat solubility affect recovery from anesthesia?1-4

Fatty tissues

  • Inhaled anesthetics move much more slowly into fat compared to highly blood-perfused tissues.5
  • At the end of the typical anesthetic case (2-4 h), very little anesthetic has entered into the fat, even with a relatively fat-soluble anesthetic.5
  • The small amount of anesthetic in the fat does not appear to affect recovery.1-4

Vessel-Rich Tissues

  • Inhaled anesthetics move rapidly into the highly blood-perfused tissues (vessel-rich group*)5

*Vessel-rich group: brain, heart, liver, kidney, and endocrine glands

Note: Vessel-poor group (ligaments, tendons, bone, and cartilage, not pictured) comprises 29% of body mass but receives 0% perfusion as a percentage of cardiac output.

Muscle Tissues

  • Inhaled anesthetics move much more slowly into fat compared to highly blood-perfused tissues.5

Low solubility in blood that facilitates rapid induction and elimination1,6-8

solubillity

Blood/gas solubility drives emergence from anesthesia6

Safety Considerations1

Due to ULTANE's insolubility in blood, hemodynamic changes may occur more rapidly than with other volatile anesthetics. Excessive decreases in blood pressure or respiratory depression may be related to depth of anesthesia and may be corrected by decreasing the inspired concentration of ULTANE.